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Tenaxit 0.5mg+10mg Tablet 1 Strip
Flupentixol and Melitracen tablets are indicated for the treatment of various depressive and anxiety-related conditions, including:
- Generalized anxiety and depressive disorders
- Apathy and lack of motivation
- Psychogenic depression
- Neurotic depression and masked depression
- Psychosomatic conditions associated with anxiety and apathy
- Menopausal mood disturbances
- Dysphoria and depression in individuals with a history of alcohol or drug abuse
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✅ Description:
This combination unites two clinically established agents:
- Flupentixol, a neuroleptic with intrinsic antidepressant and anti-anxiety activity in low doses
- Melitracen, a thymoleptic antidepressant with stimulating effects in mild to moderate depression
The synergistic effect results in improved mood, reduced anxiety, and increased motivation. Peak blood levels are typically achieved within 4 hours of oral dosing. The half-lives are approximately 35 hours for flupentixol and 19 hours for melitracen. No significant pharmacokinetic interactions occur between the two ingredients.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Each tablet contains:
- Flupentixol 0.5 mg – an antipsychotic with anxiolytic and mild antidepressant effects
- Melitracen 10 mg – a tricyclic antidepressant with energizing and mood-stabilizing properties
✔️ Dosage & Administration
Adults:
- Common dose: 2 tablets daily, one in the morning and one at noon
- Severe cases: May increase morning dose to 2 tablets
Elderly patients:
- Usually 1 tablet in the morning
Maintenance therapy:
- Typically 1 tablet daily in the morning
- In cases of insomnia or acute restlessness, an additional sedative may be prescribed during initial treatment.
✔️ Overdose Management
Symptoms of overdose typically reflect melitracen toxicity, including anticholinergic effects. Less frequently, extrapyramidal symptoms may result from flupentixol.
Management includes:
- Immediate gastric lavage
- Activated charcoal administration
- Supportive care for cardiovascular and respiratory functions
- Avoid epinephrine (adrenaline)
- Diazepam may be used to control convulsions
- Biperiden may be used to manage extrapyramidal reactions
✔️ Side Effects
- Side effects are uncommon at recommended doses. Some individuals may experience:
- Restlessness
- Difficulty sleeping (insomnia)
- These effects are usually mild and transient.
✔️ Words of Advice:
- This medicine treats depression and anxiety effectively
- Can cause drowsiness—avoid driving or hazardous tasks
- Do not consume alcohol during treatment
- Monitor blood sugar if you are diabetic
- Report any mood swings or unusual thoughts to your doctor
✔️ Drug Interactions
- May enhance the sedative effects of alcohol, barbiturates, and CNS depressants
- Concurrent use with MAO inhibitors can cause hypertensive crises; avoid co-administration or use within 14 days of MAOIs
- May reduce the efficacy of antihypertensive drugs such as guanethidine
- May potentiate the action of adrenaline or noradrenaline
✔️ Contraindications
- Recent myocardial infarction recovery phase
- Cardiac conduction abnormalities (e.g., bundle-branch block)
- Untreated narrow-angle glaucoma
- Acute intoxication from alcohol, opioids, or barbiturates
- Use of MAO inhibitors within the past two weeks
- Not suitable for hyperactive or excitable patients due to its activating effects
✔️ Use in Pregnancy & Lactation
- This medication is not recommended during pregnancy or breastfeeding due to insufficient safety data. Use only if the potential benefit justifies the risk.
- Precautions & Warnings
- Discontinue other sedative medications gradually if switching to this therapy
- Monitor closely for signs of mood changes or suicidal ideation, particularly at treatment initiation
- Caution advised in patients with liver impairment, cardiovascular disease, glaucoma, urinary retention, or thyroid dysfunction
✔️ Storage Conditions
- Store below 30°C in a dry place
- Protect from direct light
- Keep out of reach of children
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
